Increased expression of N-myristoyltransferase in gallbladder carcinomas
نویسندگان
چکیده
منابع مشابه
Expression Determines Neoangiogenesis in Gallbladder Carcinomas
Neoangiogenesis may have an important role in the poor prognosis of gallbladder carcinoma. An enhanced expression of COX- was found in precancerous lesions and in gallbladder carcinoma, likely to be involved in carcinogenesis as well as in angiogenesis. To study the relationships between the COX- expression and degree of vascularization, as well as to evaluate their role in the prognosis of p...
متن کاملNMT1 (N-myristoyltransferase 1).
Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N OW8, Canada (PS, SK, RKS); Cancer Research Unit, Saskatchewan Cancer Agency, 20 Campus Drive, Saskatoon, SK S7N 4H4, Canada (PS, SK, RKS); Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5C9, Cana...
متن کاملA second mammalian N-myristoyltransferase.
N-terminal myristoylation is a cotranslational lipid modification common to many signaling proteins that often serves an integral role in the targeting and/or function of these proteins. Myristoylation is catalyzed by an enzyme activity, N-myristoyltransferase (NMT), which transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. While a sin...
متن کاملIncreased expression of endonuclease G in gastric and colorectal carcinomas.
AIMS Endonuclease G (EndoG) is a mitochondrial protein that plays a role in DNA fragmentation during apoptosis. In addition, EndoG plays a role in cell proliferation and survival. It may be important to identify EndoG protein expression to predict its function in human cancers. The aim of this study was to explore whether alteration of EndoG expression might be a characteristic of colorectal or...
متن کاملLack of increased P15INK4B protein expression in basal cell carcinomas.
BACKGROUND The basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSK). BCC might develop because of the faulty cell cycle arrest. P15INK4b is a tumor suppressor gene, involved in cell cycle arrest and inactivated in most human cancers. The role of p15INK4b protein expression in the genesis of BCC is as yet unknown. In a previous study we showed the absence of p15INK4b exp...
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ژورنال
عنوان ژورنال: Cancer
سال: 2000
ISSN: 0008-543X,1097-0142
DOI: 10.1002/(sici)1097-0142(20000501)88:9<1992::aid-cncr3>3.0.co;2-g